Kras^em4Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kras^em4Gpt
• Name: Kras proto-oncogene, GTPase; endonuclease-mediated mutation 4, GemPharmatech
• MGI ID: MGI:7576414
• Synonyms: Kras^FLEX-G12C
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^em4Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting introduced loxP-stop-loxP cassette and reversed exon 2 with the G12C mutation in the intron. Floxed sequences are likely to reverse and delete in the Kras^FLEX-G12C mouse genome when cre recombinase exists. (J:293217)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 69 strains or lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 1 reference(s)