B2m^{em1(HLA-A24.2,B2M,H2-D1)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: B2m^{em1(HLA-A24.2,B2M,H2-D1)Gpt}
• Name: beta-2 microglobulin; endonuclease-mediated mutation 1, GemPharmatech
• MGI ID: MGI:7576248
• Synonyms: b2m^{em1Cin(hHLA-A24.2,hB2m,H2-D1)}
• Gene: B2m Location: Chr2:121978168-121983563 bp, + strand Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
• Alliance: B2m^{em1(HLA-A24.2,B2M,H2-D1)Gpt} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• B2m^{em1(HLA-A24.2,B2M,H2-D1)Gpt} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  B2M (567)

  B2m	(MGI:88127)

  human

  HLA-A (3105)

  H2-D1	(MGI:95896)
  H2-K1	(MGI:95904)
  H2-Q1	(MGI:95928)
  H2-Q2	(MGI:95931)
  H2-Q4	(MGI:95933)
  H2-Q6	(MGI:95935)
  H2-Q7	(MGI:95936)
  H2-Q10	(MGI:95929)

• Mutation details: CRISPR-targeting replaced part of the gene with a portion of the highly frequent HLA-A*24:02 gene sequence, the human B2M coding sequence, and a portion of the mouse H2-D1 coding sequence. (J:293217)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B2m Mutation: 122 strains or lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 1 reference(s)