Zfp746^em1Tmd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp746^em1Tmd
• Name: zinc finger protein 746; endonuclease-mediated mutation 1, Ted M Dawson
• MGI ID: MGI:7575762
• Synonyms: PARIS^C638S
• Gene: Zfp746 Location: Chr6:48039329-48063527 bp, - strand Genetic Position: Chr6, 23.04 cM
• Alliance: Zfp746^em1Tmd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a T to A change resulting in a cysteine to serine substitution at amino acid 638 (p.C638S). (J:322197)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp746 Mutation: 20 strains or lines available

References

• Original: J:322197 Jo A, et al., PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease. Sci Transl Med. 2021 Jul 28;13(604)
• All: 1 reference(s)