Vgf^tm5Srjs
Targeted Allele Detail

Summary

• Symbol: Vgf^tm5Srjs
• Name: VGF nerve growth factor inducible; targeted mutation 5, Stephen R J Salton
• MGI ID: MGI:7574750
• Synonyms: Vgf deltaTLQP21
• Gene: Vgf Location: Chr5:137055246-137062205 bp, + strand Genetic Position: Chr5, 76.13 cM
• Alliance: Vgf^tm5Srjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:344295
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intergenic deletion, Nucleotide substitutions
• Mutation details: A targeting vector composed of an amino acid substitution of an arginine to an alanine (R576A) in the 3'region of the VGF nerve growth factor inducible (Vgf) gene inserted a 5' flanking loxP site into the Vgf 5' UTR, and a 3' flanking loxP site and FRT-flanked neomycin selection cassette into the Vgf 3 UTR. (J:344295)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vgf Mutation: 26 strains or lines available

References

• Original: J:344295 Sahu BS, et al., Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis. Mol Metab. 2023 Jul 21;76:101781
• All: 1 reference(s)