Casp6^em1Ylin
Endonuclease-mediated Allele Detail

Summary

• Symbol: Casp6^em1Ylin
• Name: caspase 6; endonuclease-mediated mutation 1, Yuanbang Lin
• MGI ID: MGI:7574632
• Synonyms: Caspase 6^KO
• Gene: Casp6 Location: Chr3:129695074-129707752 bp, + strand Genetic Position: Chr3, 59.5 cM, cytoband H1
• Alliance: Casp6^em1Ylin page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR/Cas9 technology generated a knock-out allele. Western blot analysis confirmed absence of protein in the liver. (J:344262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp6 Mutation: 16 strains or lines available

References

• Original: J:344262 Lin Y, et al., Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IkappaBalpha axis in liver inflammation. Cell Commun Signal. 2023 Oct 12;21(1):282
• All: 1 reference(s)