Kcnk5^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnk5^em1Cya
• Name: potassium channel, subfamily K, member 5; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7573099
• Synonyms: Kcnk5^flox
• Gene: Kcnk5 Location: Chr14:20190125-20231850 bp, - strand Genetic Position: Chr14, 11.43 cM, cytoband A3
• Alliance: Kcnk5^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 2-4 were flanked by loxP sites via CRISPR-targeting. (J:344162)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnk5 Mutation: 62 strains or lines available

References

• Original: J:344162 Zhang J, et al., TWIK-related acid-sensitive K(+) channel 2 promotes renal fibrosis by inducing cell-cycle arrest. iScience. 2022 Dec 22;25(12):105620
• All: 1 reference(s)