Chi3l1^em1Mul
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chi3l1^em1Mul
• Name: chitinase 3 like 1; endonuclease-mediated mutation 1, William Muller
• MGI ID: MGI:7571508
• Gene: Chi3l1 Location: Chr1:134109894-134117769 bp, + strand Genetic Position: Chr1, 58.15 cM
• Alliance: Chi3l1^em1Mul page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting exons 1 and 6 created a deletion removing exons 1 through 6. (J:343706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chi3l1 Mutation: 29 strains or lines available

References

• Original: J:343706 Taifour T, et al., The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer. Immunity. 2023 Dec 12;56(12):2755-2772.e8
• All: 2 reference(s)