Dll1^{em3.1(Dll4)Gos}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dll1^{em3.1(Dll4)Gos}
• Name: delta like canonical Notch ligand 1; endonuclease-mediated mutation 3.1, Achim Gossler
• MGI ID: MGI:7571318
• Synonyms: Dll1^D1contD4ki
• Gene: Dll1 Location: Chr17:15587616-15597134 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Dll1^{em3.1(Dll4)Gos} page

Mutation origin

• Strain of Origin: 129Sv and CAST/EiJ

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting introduced a DLL1 variant whose predicted amino acids of the MNNL and DSL domains that contact N1 are replaced with the corresponding amino acids of DLL4. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:274018)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll1 Mutation: 46 strains or lines available

References

• Original: J:274018 Tveriakhina L, et al., The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro. Elife. 2018 Oct 5;7:e40045
• All: 1 reference(s)