T(XTmsb4x-Hccs;Y)1Dto
Spontaneous Allele Detail

Summary

• Symbol: T(XTmsb4x-Hccs;Y)1Dto
• Name: translocation, Chr X, Duncan T Odom
• MGI ID: MGI:7571197
• Gene: T(XTmsb4x-Hccs;Y)1Dto Location: unknown Genetic Position: ChrY, Syntenic

Mutation origin

• Strain of Origin: B6.Cg-Tg(Sry)2Ei Sry^dl1Rlb T(XTmsb4x-Hccs;Y)1Dto/ArnoJ

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Translocation
• Mutation details: The translocation has a 3.2 MB region mapping to chrX:165.530.000 - 168.750.000 on GRCm39, and containing nine annotated genes (Tmsb4x, Tlr8, Tlr7, Prps2, Frmpd4, Msl3, Arhgap6, Amelx and Hccs), of which six are detectably upregulated, is fused to the Y chromosome. (J:343787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any T(XTmsb4x-Hccs;Y)1Dto Mutation: 1 strain or line available

References

• Original: J:343787 Panten J, et al., Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage. bioRxiv. 2023
• All: 1 reference(s)