Zfy2^em3Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfy2^em3Osb
• Name: zinc finger protein 2, Y-linked; endonuclease-mediated mutation 3, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7570172
• Synonyms: DKO2H.3B
• Gene: Zfy2 Location: ChrY:2106175-2170409 bp, - strand Genetic Position: ChrY, cytoband p
• Alliance: Zfy2^em3Osb page

Mutation origin

• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 4 deleted 5 bp and 27107 bp (J:337568)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfy2 Mutation: 28 strains or lines available

Notes

This allele was generated in the same ES cells that were also targeted for Zfy2^em3Osb.

References

• Original: J:337568 Yamauchi Y, et al., Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility. Biol Reprod. 2022 Jun 13;106(6):1312-1326
• All: 2 reference(s)