Gli3^em1Tnom
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gli3^em1Tnom
• Name: GLI-Kruppel family member GLI3; endonuclease-mediated mutation 1, Tadashi Nomura
• MGI ID: MGI:7569219
• Synonyms: Gli3^R1540C
• Gene: Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
• Alliance: Gli3^em1Tnom page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas12a technology generated a C to T change resulting in an arginine to cysteine substitution at amino acid 1540 (p.R1540C). This corresponds to the p.R1537C variant carried in Neanderthals and Denisovans, extinct hominins close to modern humans. (J:343594)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli3 Mutation: 84 strains or lines available

References

• Original: J:343594 Agata A, et al., A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice. Front Cell Dev Biol. 2023;11:1247361
• All: 1 reference(s)