P2ry1^em2Robn
Endonuclease-mediated Allele Detail

Summary

• Symbol: P2ry1^em2Robn
• Name: purinergic receptor P2Y, G-protein coupled 1; endonuclease-mediated mutation 2, Robert A Nicholas
• MGI ID: MGI:7569186
• Gene: P2ry1 Location: Chr3:60910216-60916403 bp, + strand Genetic Position: Chr3, 29.24 cM, cytoband E1
• Alliance: P2ry1^em2Robn page

Mutation origin

• Strain of Origin: C57BL/6NHsd

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutation: Insertion
• Mutation details: Sequence coding for an HA tag was inserted immediately after the start codon using an sgRNA (targeting GGAAAGAAGAGGATGACCG) and an ssODN template with CRISPR/Cas9 technology. (J:342773)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry1 Mutation: 31 strains or lines available

References

• Original: J:342773 Paul DS, et al., Loss of P2Y(1) receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro. J Thromb Haemost. 2023 Jul;21(7):1891-1902
• All: 1 reference(s)