Mtor^em1Shmsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mtor^em1Shmsh
• Name: mechanistic target of rapamycin kinase; endonuclease-mediated mutation 1, Shao-Ming Shen
• MGI ID: MGI:7569135
• Synonyms: Mtor^KR
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^em1Shmsh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a lysine to arginine substitution at amino acid 2066 (p.K2066R) in exon 44. (J:343575)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 117 strains or lines available

References

• Original: J:343575 Ge MK, et al., The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency. Cell Metab. 2023 Dec 5;35(12):2216-2230.e8
• All: 1 reference(s)