Arsb^tm1.1Anec
Targeted Allele Detail

Summary

• Symbol: Arsb^tm1.1Anec
• Name: arylsulfatase B; targeted mutation 1.1, Aris Economides
• MGI ID: MGI:7569014
• Synonyms: Arsb^COIN
• Gene: Arsb Location: Chr13:93908187-94079524 bp, + strand Genetic Position: Chr13, 47.88 cM
• Alliance: Arsb^tm1.1Anec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343559
• Parent Cell Line: VGF1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A conditional by inversion (COIN) module consisting of a lox66, exon 5, and lox71 was inserted in the antisense orientation replacing exon 5. In addition, a rox flanked self-deleting drug selection cassette consisting of Prm1 promoter, Drei cDNA, SV40pA, UBC promoter, pEM7, neomycin cDNA and Pgk1 pAk was inserted after the COIN module. The drug selection cassette was self-excised. This is a null allele as exon 5 is in the antisense orientation. (J:343559)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arsb Mutation: 26 strains or lines available

References

• Original: J:343559 Hwang-Wong E, et al., Skeletal phenotype amelioration in mucopolysaccharidosis VI requires intervention at the earliest stages of postnatal development. JCI Insight. 2023 Nov 8;8(21)
• All: 1 reference(s)