Cacna1b^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Cacna1b^tm1.1Arte
• Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:7568834
• Synonyms: Cacna1b^KI-HA
• Gene: Cacna1b Location: Chr2:24493899-24653164 bp, - strand Genetic Position: Chr2, 16.58 cM, cytoband A2
• Alliance: Cacna1b^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269262
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: The targeting construct introduced two HA tags into exon 13. Flp-mediated recombination removed the FRT puromycin cassette inserted into intron 13. (J:269262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1b Mutation: 104 strains or lines available

References

• Original: J:269262 Nieto-Rostro M, et al., Ablation of alpha2delta-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12043-E12052
• All: 1 reference(s)