Gt(ROSA)26Sor^{tm2(CAG-GLuc)Thst}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-GLuc)Thst}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Thorsten Stiewe
• MGI ID: MGI:7567847
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-GLuc)Thst} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332769
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The ubiquitous gene locus carries an inducible Gaussia luciferase under the CAG promoter. After cre recombination the Gaussia luciferase is secreted into the blood. It can be used as a reporter to measure tumor growth by blood sampling. (J:332769)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:332769 Merle N, et al., Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase. Mol Cancer. 2022 Oct 3;21(1):191
• All: 1 reference(s)