Trp53^em1Milu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trp53^em1Milu
• Name: transformation related protein 53; endonuclease-mediated mutation 1, Min Lu
• MGI ID: MGI:7567689
• Synonyms: p53^R279W
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^em1Milu page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a CGC to TGG change resulting in an arginine to tryptophan substitution at amino acid 279 (p.R279W). This corresponds to the p.R282W mutation identified in an individual with Li-Fraumeni syndrome. (J:343272)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^em1Milu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 237 strains or lines available

References

• Original: J:343272 Li J, et al., Arsenic trioxide extends survival of Li-Fraumeni syndrome mimicking mouse. Cell Death Dis. 2023 Nov 29;14(11):783
• All: 1 reference(s)