Kynu^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Kynu^tm1Smoc
• Name: kynureninase; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7567514
• Synonyms: Kynu^{tm1(flox)Smoc}
• Gene: Kynu Location: Chr2:43445341-43572734 bp, + strand Genetic Position: Chr2, 25.64 cM, cytoband C1
• Alliance: Kynu^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343427
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exon 4 was flanked by loxP sites via CRISPR/Cas9 technology. (J:343427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kynu Mutation: 34 strains or lines available

References

• Original: J:343427 Wan J, et al., De novo NAD(+) synthesis contributes to CD8(+) T cell metabolic fitness and antitumor function. Cell Rep. 2023 Dec 1;42(12):113518
• All: 1 reference(s)