Tg(Itgax-H2-Ab1)1Tml
Transgene Detail

Summary

• Symbol: Tg(Itgax-H2-Ab1)1Tml
• Name: transgene insertion 1, Terri M Laufer
• MGI ID: MGI:7565574
• Synonyms: CD11c/Abetab
• Transgene: Tg(Itgax-H2-Ab1)1Tml Location: unknown
• Alliance: Tg(Itgax-H2-Ab1)1Tml page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Itgax-H2-Ab1)1Tml expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-Ab1 (MGI:103070)

• Mutation details: The transgenic construct contains the mouse Itgax (integrin alpha X or Cd11c) promoter directing expression of the endogenous mouse H2-Ab1 gene (I-A(b)) cDNA. Founder line 1 had 90% expression of MHC class II on dendritic cells. (J:169793)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:169793 Lemos MP, et al., CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity. J Immunol. 2003 Nov 15;171(10):5077-84
• All: 1 reference(s)