Cfh^tm1.2Hohj
Targeted Allele Detail

Summary

• Symbol: Cfh^tm1.2Hohj
• Name: complement component factor h; targeted mutation 1.2, Josephine Hoh
• MGI ID: MGI:7565418
• Gene: Cfh Location: Chr1:140013593-140111149 bp, - strand Genetic Position: Chr1, 61.62 cM, cytoband F
• Alliance: Cfh^tm1.2Hohj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257103
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3, and a FRT-flanked PGK-neomycin cassette followed by a loxP-site upstream of exon 4. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 3. (J:257103)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfh Mutation: 98 strains or lines available

References

• Original: J:257103 Liu J, et al., Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration. J Cancer. 2017;8(12):2184-2190
• All: 1 reference(s)