Piwil1^em1Cchen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Piwil1^em1Cchen
• Name: piwi-like RNA-mediated gene silencing 1; endonuclease-mediated mutation 1, Chen Chen
• MGI ID: MGI:7565296
• Synonyms: Miwi^RK
• Gene: Piwil1 Location: Chr5:128813135-128832538 bp, + strand Genetic Position: Chr5, 67.86 cM
• Alliance: Piwil1^em1Cchen page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• All six arginines in the N-terminal RG motif were changed to lysines via CRISPR/Cas9 technology. (J:343260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Piwil1 Mutation: 29 strains or lines available

References

• Original: J:343260 Wei C, et al., MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing. PLoS Genet. 2023 Nov;19(11):e1011031
• All: 1 reference(s)