Tincr^em1Aafo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tincr^em1Aafo
• Name: TINCR ubiquitin domain containing; endonuclease-mediated mutation 1, Adolfo A Ferrando
• MGI ID: MGI:7564268
• Synonyms: Tincrp.Arg6Thrfs*, Tincr^p.R6fs
• Gene: Tincr Location: Chr17:56858414-56861403 bp, - strand Genetic Position: Chr17, 29.39 cM
• Alliance: Tincr^em1Aafo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:334066
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a single nucleotide resulting in a frameshift mutation and premature termination (p.Arg6Thrfs*33). (J:334066)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tincr Mutation: 2 strains or lines available

References

• Original: J:334066 Morgado-Palacin L, et al., The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma. Nat Commun. 2023 Mar 10;14(1):1328
• All: 1 reference(s)