Mylk^tm2Avs
Targeted Allele Detail

Summary

• Symbol: Mylk^tm2Avs
• Name: myosin, light polypeptide kinase; targeted mutation 1, A Somlyo
• MGI ID: MGI:7564212
• Gene: Mylk Location: Chr16:34565580-34822790 bp, + strand Genetic Position: Chr16, 24.49 cM
• Alliance: Mylk^tm2Avs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341375
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting construct is designed to remove a 30-nucleotide telokin promoter sequence containing the AT-rich region and the CArG box of the gene by insertion of a loxP-flanked neomycin cassette. (J:341375)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mylk Mutation: 104 strains or lines available

References

• Original: J:341375 Kalra J, et al., p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle. Front Physiol. 2023;14:1228488
• All: 1 reference(s)