Psmc1^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Psmc1^em1Bcgen
• Name: protease (prosome, macropain) 26S subunit, ATPase 1; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7564153
• Synonyms: Psmc1^G2A
• Gene: Psmc1 Location: Chr12:100076461-100089623 bp, + strand Genetic Position: Chr12, 50.43 cM
• Alliance: Psmc1^em1Bcgen page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Altered localization)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination created a G to A amino acid substitution at position 2 that disrupts N-myristoylation and impairs membrane association of the protein. (J:343081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc1 Mutation: 23 strains or lines available

References

• Original: J:343081 Zhang R, et al., Lipid-anchored proteasomes control membrane protein homeostasis. Sci Adv. 2023 Dec;9(48):eadj4605
• All: 1 reference(s)