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Syngap1em2Xiaoz
Endonuclease-mediated Allele Detail
Summary
Symbol: Syngap1em2Xiaoz
Name: synaptic Ras GTPase activating protein 1 homolog (rat); endonuclease-mediated mutation 2, Xiaochang Zhang
MGI ID: MGI:7564136
Synonyms: Syngap1-NISO S
Gene: Syngap1  Location: Chr17:27160227-27191408 bp, + strand  Genetic Position: Chr17, 13.6 cM
Alliance: Syngap1em2Xiaoz page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Intragenic deletion
 
Mutation detailsIntron 10 was targeted with two sgRNAs using CRISPR/Cas9 technology, resulting in a 169 bp deletion (GRCm39:chr17:27178159-27178327). This deletion does not eliminate the alternative 3' splice acceptor site that is used for NMD-mediated transcriptional regulation. (J:334714)
Expression
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syngap1 Mutation:  49 strains or lines available
References
Original:  J:334714 Yang R, et al., Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron. 2023 Mar 3;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory