Syngap1^em1Xiaoz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Syngap1^em1Xiaoz
• Name: synaptic Ras GTPase activating protein 1 homolog (rat); endonuclease-mediated mutation 1, Xiaochang Zhang
• MGI ID: MGI:7564128
• Synonyms: Syngap1-NISO N
• Gene: Syngap1 Location: Chr17:27160227-27191408 bp, + strand Genetic Position: Chr17, 13.6 cM
• Alliance: Syngap1^em1Xiaoz page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: Intron 10 was targeted with two sgRNAs using CRISPR/Cas9 technology, resulting in a 268 bp deletion (GRCm39:chr17:27178158-27178425). This deletion eliminates the alternative 3' splice acceptor site that is used for NMD-mediated transcriptional regulation. (J:334714)

Expression

In Mice Carrying this Mutation:

35 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syngap1 Mutation: 49 strains or lines available

References

• Original: J:334714 Yang R, et al., Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron. 2023 Mar 3
• All: 1 reference(s)