Padi4^em1Icr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Padi4^em1Icr
• Name: peptidyl arginine deiminase, type IV; endonuclease-mediated mutation 1, Inflammation Research Center
• MGI ID: MGI:7562579
• Synonyms: PAD4^-, Padi4^em1Gvl
• Gene: Padi4 Location: Chr4:140473176-140501547 bp, - strand Genetic Position: Chr4, 72.34 cM, cytoband E1
• Alliance: Padi4^em1Icr page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 62 bp deletion in exon 5. This is predicted to result in a premature codon resulting in nonsense-mediated decay. (J:343044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Padi4 Mutation: 46 strains or lines available

References

• Original: J:343044 Van Damme KFA, et al., Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice. Sci Rep. 2023 Oct 21;13(1):17992
• All: 1 reference(s)