Apoe^{tm1(APOE*)Ljohn}
Targeted Allele Detail

Summary

• Symbol: Apoe^{tm1(APOE*)Ljohn}
• Name: apolipoprotein E; targeted mutation 1, Lance Johnson
• MGI ID: MGI:7562448
• Synonyms: 4s2, APOE switch
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^{tm1(APOE*)Ljohn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutation: Insertion
• Apoe^{tm1(APOE*)Ljohn} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

  exons 2-4

• Mutation details: Human APOE exons 2-4 were inserted into the mouse Apoe genomic sequence replacing mouse exons 2-4. In addition, human exon 4 and a stop codon are flanked by loxP sites followed by exon 4 from the APOE2 isoform, providing a conditional "switch". (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 163 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)