Tg(S100A8-NRAS*G12D)1Bop
Transgene Detail

Summary

• Symbol: Tg(S100A8-NRAS*G12D)1Bop
• Name: transgene insertion 1, J Michael Bishop
• MGI ID: MGI:7562248
• Synonyms: hMRP8-NRASG12D
• Transgene: Tg(S100A8-NRAS*G12D)1Bop Location: unknown
• Alliance: Tg(S100A8-NRAS*G12D)1Bop page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(S100A8-NRAS*G12D)1Bop expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NRAS (4893)

  Nras	(MGI:97376)

• Tg(S100A8-NRAS*G12D)1Bop expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  S100A8 (6279)

  S100a8

  (MGI:88244)

• Mutation details: The human promoter drives expression of the human gene with the mutation responsible for the amino acid substitution of glycine with aspartic acid at position 12 (G12D). (J:50146)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:50146 Kogan SC, et al., The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11863-8
• All: 2 reference(s)