Slc39a14^em1Crj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc39a14^em1Crj
• Name: solute carrier family 39 (zinc transporter), member 14; endonuclease-mediated mutation 1, Robert J Cousins
• MGI ID: MGI:7562111
• Synonyms: Zip14^fl, Zip14^flox
• Gene: Slc39a14 Location: Chr14:70540918-70588874 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Slc39a14^em1Crj page

Mutation origin

• Strain of Origin: 129

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted in introns 4 and 8 via CRISPR/Cas9 technology. (J:294356)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a14 Mutation: 71 strains or lines available

References

• Original: J:294356 Aydemir TB, et al., Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism. Am J Physiol Gastrointest Liver Physiol. 2020 Apr 1;318(4):G673-G681
• All: 5 reference(s)