Tbx20^em1Flc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tbx20^em1Flc
• Name: T-box 20; endonuclease-mediated mutation 1, Frank Conlon
• MGI ID: MGI:7562102
• Synonyms: Tbx20^EH1Mut
• Gene: Tbx20 Location: Chr9:24632108-24685580 bp, - strand Genetic Position: Chr9, 10.25 cM
• Alliance: Tbx20^em1Flc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination created a 2 amino acid substitution (phenylalanine 18 and serine 19 to leucine and isoleucine, respectively) that disrupts the interaction with Transducin-like Enhancer of Split proteins. (J:342149)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx20 Mutation: 36 strains or lines available

References

• Original: J:342149 Edwards W, et al., The Tbx20-TLE interaction is essential for the maintenance of the second heart field. Development. 2023 Nov 1;150(21):dev201677
• All: 1 reference(s)