Rela^tm1.1Alex
Targeted Allele Detail

Summary

• Symbol: Rela^tm1.1Alex
• Name: Rela proto-oncogene, NFKB subunit; targeted mutation 1.1, Alexander Hoffman
• MGI ID: MGI:7562030
• Synonyms: Rela^TA
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1.1Alex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288116
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Intragenic deletion, Nucleotide substitutions
• Mutation details: The targeting vector is designed to replace residues 520-549 of the gene with an FRT-flanked neomycin cassette. This construct also contains two point mutations, L449A and F473A, in exon 11. Flp-mediated recombination removed the neo cassette. (J:288116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:288116 Ngo KA, et al., Dissecting the Regulatory Strategies of NF-kappaB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics. Cell Rep. 2020 Feb 25;30(8):2758-2775.e6
• All: 1 reference(s)