Top2a^tm1.1Heche
Endonuclease-mediated Allele Detail

Summary

• Symbol: Top2a^tm1.1Heche
• Name: topoisomerase (DNA) II alpha; targeted mutation 1.1, Cheng He
• MGI ID: MGI:7562000
• Synonyms: Top2a^F, Top2a^Loxp
• Gene: Top2a Location: Chr11:98883769-98915015 bp, - strand Genetic Position: Chr11, 62.91 cM
• Alliance: Top2a^tm1.1Heche page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked by loxP sites. An FRT-flanked selection cassette was inserted and removed via flp-mediated recombination. (J:328936)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Top2a Mutation: 92 strains or lines available

References

• Original: J:328936 Qin S, et al., Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37. Nucleic Acids Res. 2022 Aug 27
• All: 1 reference(s)