Camk2a^em2Rjco
Endonuclease-mediated Allele Detail

Summary

• Symbol: Camk2a^em2Rjco
• Name: calcium/calmodulin-dependent protein kinase II alpha; endonuclease-mediated mutation 2, Roger J Colbran
• MGI ID: MGI:7550777
• Gene: Camk2a Location: Chr18:61058704-61121224 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Camk2a^em2Rjco page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated an 11 bp (TGCTGAGGAAG) deletion in exon 8, leading to a frameshift and early translational termination. (J:286220)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2a Mutation: 135 strains or lines available

References

• Original: J:286220 Marks CR, et al., Activated CaMKIIalpha Binds to the mGlu5 Metabotropic Glutamate Receptor and Modulates Calcium Mobilization. Mol Pharmacol. 2018 Dec;94(6):1352-1362
• All: 2 reference(s)