Prep^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prep^em1Smoc
• Name: prolyl endopeptidase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7550671
• Synonyms: PREP^gt
• Gene: Prep Location: Chr10:44943312-45038847 bp, + strand Genetic Position: Chr10, 23.27 cM, cytoband B2-B3
• Alliance: Prep^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1,352 bp partial deletion of exon 3. Western blot analysis confirmed absence of protein in the liver. (J:287145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prep Mutation: 53 strains or lines available

References

• Original: J:287145 Jiang DX, et al., Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation. Ann Transl Med. 2020 Mar;8(5):218
• All: 2 reference(s)