Sycp1^em2Hawl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sycp1^em2Hawl
• Name: synaptonemal complex protein 1; endonuclease-mediated mutation 2, R Scott Hawley
• MGI ID: MGI:7550380
• Synonyms: Sycp1^L106E
• Gene: Sycp1 Location: Chr3:102725815-102843416 bp, - strand Genetic Position: Chr3, 45.25 cM, cytoband A3
• Alliance: Sycp1^em2Hawl page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a leucine to glutamic acid substitution at amino acid 106 (p.L106E) targeting SYCP1s head-to-head interface. This corresponds to human L109. (J:342558)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sycp1 Mutation: 58 strains or lines available

References

• Original: J:342558 Billmyre KK, et al., SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis. Sci Adv. 2023 Oct 20;9(42):eadi1562
• All: 1 reference(s)