Mettl3^em2Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl3^em2Cya
• Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; endonuclease-mediated mutation 2, Cyagen Biosciences
• MGI ID: MGI:7549389
• Synonyms: Mettl3^f
• Gene: Mettl3 Location: Chr14:52532298-52542585 bp, - strand Genetic Position: Chr14, 26.88 cM, cytoband C1
• Alliance: Mettl3^em2Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 2 through 4 were floxed. (J:338536)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl3 Mutation: 42 strains or lines available

References

• Original: J:338536 Wei T, et al., Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation. Cell Rep. 2023 Jul 25;42(7):112704
• All: 1 reference(s)