Mpc2^{tm1.1(tetO)Itl}
Targeted Allele Detail

Summary

• Symbol: Mpc2^{tm1.1(tetO)Itl}
• Name: mitochondrial pyruvate carrier 2; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:7549369
• Gene: Mpc2 Location: Chr1:165288829-165308787 bp, + strand Genetic Position: Chr1, 72.8 cM, cytoband H2
• Alliance: Mpc2^{tm1.1(tetO)Itl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338776
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a FAST (Flexible Accelerated STOP Tetracycline Operator (tetO)-knock-in) construct upstream of the endogenous ATG initiation site in exon 1. Flp-mediated recombination removed the neomycin resistance cassette. (J:338776)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mpc2 Mutation: 14 strains or lines available

References

• Original: J:338776 Fernandez-Caggiano M, et al., Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy. Nat Metab. 2020 Nov;2(11):1223-1231
• All: 1 reference(s)