Prkd2^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkd2^M1Btlr
• Name: protein kinase D2; mutation 1, Bruce Beutler
• MGI ID: MGI:7549277
• Synonyms: Prkd2^Pur, Purnama
• Gene: Prkd2 Location: Chr7:16576827-16604386 bp, + strand Genetic Position: Chr7, 9.15 cM
• Alliance: Prkd2^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T-to-A mutation changing tryptophan codon 807 (TGG) in exon 17 to arginine (AGG) (p.W807R). The mutation is associated with increased serum concentrations of total and OVA-specific IgE after OVA/alum challenge. (J:296761)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkd2 Mutation: 43 strains or lines available

References

• Original: J:296761 Misawa T, et al., Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation. Sci Immunol. 2020 Jan 24;5(43)
• All: 1 reference(s)