Frmd8^em2Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Frmd8^em2Smoc
• Name: FERM domain containing 8; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7549274
• Synonyms: Frmd8^fl
• Gene: Frmd8 Location: Chr19:5901002-5925297 bp, - strand Genetic Position: Chr19, 4.34 cM, cytoband A
• Alliance: Frmd8^em2Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 4 through 6. (J:338904)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frmd8 Mutation: 21 strains or lines available

References

• Original: J:338904 Yu M, et al., FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth. Cell Rep. 2023 Jul 31;42(8):112886
• All: 1 reference(s)