Galns^em1Toma
Endonuclease-mediated Allele Detail

Summary

• Symbol: Galns^em1Toma
• Name: galactosamine (N-acetyl)-6-sulfatase; endonuclease-mediated mutation 1, Shunji Tomatsu
• MGI ID: MGI:7548874
• Synonyms: MPS IVA
• Gene: Galns Location: Chr8:123304981-123338202 bp, - strand Genetic Position: Chr8, 71.91 cM
• Alliance: Galns^em1Toma page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two pairs of sgRNAs were cleaved together to generate a large approximately 6300 bp deletion between the two target sites (up- and downstream of the Galns gene). GALNS enzyme activity is not detectable in tissues and blood of homozygotes. (J:342524)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Galns Mutation: 26 strains or lines available

References

• Original: J:342524 Rintz E, et al., Bone Growth Induction in Mucopolysaccharidosis IVA Mouse. Int J Mol Sci. 2023 Jun 8;24(12)
• All: 1 reference(s)