Tg(Prnp-Ldlr)BHol
Transgene Detail

Summary

• Symbol: Tg(Prnp-Ldlr)BHol
• Name: transgene insertion B, David M Holtzman
• MGI ID: MGI:7548804
• Transgene: Tg(Prnp-Ldlr)BHol Location: unknown
• Alliance: Tg(Prnp-Ldlr)BHol page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-Ldlr)BHol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ldlr (MGI:96765)

• Tg(Prnp-Ldlr)BHol expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: A mouse Prnp promoter drives expression of a mouse Ldlr cDNA. Two lines were generated, a high-expressing B line and low-expressing E line. (J:155809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:155809 Kim J, et al., Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 2009 Dec 10;64(5):632-44
• All: 4 reference(s)