Mlkl^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em1Smoc
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7548774
• Synonyms: Mlkl^{em1(flox)Smoc}
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exon 3. (J:339119)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 34 strains or lines available

References

• Original: J:339119 Yan M, et al., Targeting Endothelial Necroptosis Disrupts Profibrotic Endothelial-Hepatic Stellate Cells Crosstalk to Alleviate Liver Fibrosis in Nonalcoholic Steatohepatitis. Int J Mol Sci. 2023 Jul 11;24(14)
• All: 1 reference(s)