Flt4^tm1.1Mlkn
Targeted Allele Detail

Summary

• Symbol: Flt4^tm1.1Mlkn
• Name: FMS-like tyrosine kinase 4; targeted mutation 1.1, Mark Kahn
• MGI ID: MGI:7548717
• Synonyms: Flt4^fl
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^tm1.1Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339458
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exon 3 and placed an FRT-flanked neomycin resistance cassette upstream of the first loxP site. Flp-mediated recombination removed the selection cassette. (J:339458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 77 strains or lines available

References

• Original: J:339458 Keller TCS 4th, et al., Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction. J Clin Invest. 2021 Oct 15;131(20):e147070
• All: 3 reference(s)