Mavs^tm1.1Mbp
Targeted Allele Detail

Summary

• Symbol: Mavs^tm1.1Mbp
• Name: mitochondrial antiviral signaling protein; targeted mutation 1.1, Mouse Biology Program, UC Davis
• MGI ID: MGI:7548471
• Synonyms: MAVS^fl
• Gene: Mavs Location: Chr2:131075983-131089945 bp, + strand Genetic Position: Chr2, 63.3 cM
• Alliance: Mavs^tm1.1Mbp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340293
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 3 and an FRT-flanked neomycin resistance cassette with a 3' loxP site. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:340293)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mavs Mutation: 38 strains or lines available

References

• Original: J:340293 Roe K, et al., Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses. PLoS One. 2019;14(6):e0218928
• All: 3 reference(s)