Mff^tm1.1Ogw
Targeted Allele Detail

Summary

• Symbol: Mff^tm1.1Ogw
• Name: mitochondrial fission factor; targeted mutation 1.1, Yoshihiro Ogawa
• MGI ID: MGI:7548323
• Gene: Mff Location: Chr1:82702611-82730115 bp, + strand Genetic Position: Chr1, 42.45 cM
• Alliance: Mff^tm1.1Ogw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342282
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 3 and a floxed neomycin resistance cassette downstream of exon 4. Cre-mediated recombination removed exons 3 and 4, and the selection cassette. (J:342282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mff Mutation: 27 strains or lines available

References

• Original: J:342282 Takeichi Y, et al., Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. Diabetologia. 2021 Sep;64(9):2092-2107
• All: 1 reference(s)