Slitrk2^tm1.1Jwum
Targeted Allele Detail

Summary

• Symbol: Slitrk2^tm1.1Jwum
• Name: SLIT and NTRK-like family, member 2; targeted mutation 1.1, Ji Won Um
• MGI ID: MGI:7547409
• Synonyms: Slitrk2 flox
• Gene: Slitrk2 Location: ChrX:65692924-65704999 bp, + strand Genetic Position: ChrX, 34.81 cM, cytoband A5
• Alliance: Slitrk2^tm1.1Jwum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342291
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 3. The neomycin cassette was removed via flp-mediated recombination, leaving exon 2, 3, and the 3 UTR floxed. (J:342291)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slitrk2 Mutation: 5 strains or lines available

References

• Original: J:342291 El Chehadeh S, et al., SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice. Nat Commun. 2022 Jul 15;13(1):4112
• All: 1 reference(s)