Mptx2^em1Ngao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mptx2^em1Ngao
• Name: mucosal pentraxin 2; endonuclease-mediated mutation 1, Nan Gao
• MGI ID: MGI:7547356
• Synonyms: Mptx2delta19
• Gene: Mptx2 Location: Chr1:173102028-173105323 bp, - strand Genetic Position: Chr1, 80.33 cM
• Alliance: Mptx2^em1Ngao page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 19-bp deletion (TTCACAGACCTGACTCGCC) in exon 2, resulting in a frame-shift and premature stop codon. Western blot analysis confirmed absence of protein in ileum lysates of homozygotes. (J:342295)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mptx2 Mutation: 15 strains or lines available

References

• Original: J:342295 Balasubramanian I, et al., Infection and inflammation stimulate expansion of a CD74(+) Paneth cell subset to regulate disease progression. EMBO J. 2023 Nov 2;42(21):e113975
• All: 1 reference(s)