Tfrc^tm1Kpan
Targeted Allele Detail

Summary

• Symbol: Tfrc^tm1Kpan
• Name: transferrin receptor; targeted mutation 1, Kostas Pantopoulos
• MGI ID: MGI:7546986
• Synonyms: Tfrc^fl
• Gene: Tfrc Location: Chr16:32427738-32451612 bp, + strand Genetic Position: Chr16, 23.06 cM
• Alliance: Tfrc^tm1Kpan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273037
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 3 and 4. FLP-mediated recombination removed an FRT flanked neomycin resistance cassette. (J:273037)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfrc Mutation: 64 strains or lines available

References

• Original: J:273037 Fillebeen C, et al., Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. Blood. 2019 Jan 24;133(4):344-355
• All: 3 reference(s)