Alkbh5^em1Chhe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Alkbh5^em1Chhe
• Name: alkB homolog 5, RNA demethylase; endonuclease-mediated mutation 1, Chuan He
• MGI ID: MGI:7545678
• Synonyms: Alkbh5(Em-ko)
• Gene: Alkbh5 Location: Chr11:60428509-60449338 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Alkbh5^em1Chhe page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted part of exon 1. (J:342104)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh5 Mutation: 17 strains or lines available

References

• Original: J:342104 Shen C, et al., RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia. Cell Stem Cell. 2020 Jul 2;27(1):64-80.e9
• All: 1 reference(s)